Latency using any Cloud application with 49" Inch Monitor ( using 5K resolution [5120*1440] )

After switching from On-Prem 1912 CU6 to Cloud 2203 CU3 - There is sluggish performance using a higher resolution monitors & increased in number of Monitors - Problem appears on 6 monitors with a resolution of 19201200 - Problemappears on 1x monitor with 49" curved monitor with a resolution of...