GeneBreaker: Jailbreak Attacks against DNA Language Models with Pathogenicity Guidance

DNA, encoding genetic instructions for almost all living organisms, fuels groundbreaking advances in genomics and synthetic biology. Recently, DNA Foundation Models have achieved success in designing synthetic functional DNA sequences, even whole genomes, but their susceptibility to jailbreaking...

MAI-2025-0022

DNA language models, particularly those within the Evo series, are susceptible to sophisticated jailbreak attacks that facilitate the generation of DNA sequences exhibiting high similarity to known human pathogens. The GeneBreaker framework exemplifies this vulnerability by employing meticulously...