OESA-2026-3491 htslib security update

HTSlib is an implementation of a unified C library for accessing common file formats, such as SAM, CRAM and VCF, used for high-throughput sequencing data, and is the core library used by samtools and bcftools. HTSlib only depends on zlib. It is known to be compatible with gcc, g++ and clang. HTSl...

OESA-2026-2757 htslib security update

HTSlib is an implementation of a unified C library for accessing common file formats, such as SAM, CRAM and VCF, used for high-throughput sequencing data, and is the core library used by samtools and bcftools. HTSlib only depends on zlib. It is known to be compatible with gcc, g++ and clang. HTSl...

CVE-2026-31962 HTSlib CRAM reader has heap buffer overflow due to improper validation of input

HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. While most alignment records store DNA sequence and quality values, the format also allows them to omit this data in certain cases to save space. Due to...

CVE-2026-31962 HTSlib CRAM reader has heap buffer overflow due to improper validation of input

HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. While most alignment records store DNA sequence and quality values, the format also allows them to omit this data in certain cases to save space. Due to...

CVE-2026-31966: Out-of-bounds Read

HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. As one method of removing redundant data, CRAM uses reference-based compression so that instead of storing the full sequence for each alignment record it...

CVE-2026-31962: Heap-based Buffer Overflow

HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. While most alignment records store DNA sequence and quality values, the format also allows them to omit this data in certain cases to save space. Due to...

HTSlib 缓冲区错误漏洞

HTSlib is a C-language library file developed by samtools. Versions of HTSlib prior to 1.23.1, 1.22.2, and 1.21.1 have a buffer error vulnerability. This vulnerability stems from improper handling of the cramdecodeseq function, which may lead to a heap buffer overflow...